Standard Name	CKB1
Systematic Name	YGL019W
Feature Type	ORF, Verified
Description	Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases (1, 2)
Name Description	Casein Kinase Beta subunit
Gene Product Alias	CK2 subunit 3

Chromosomal Location	ChrVII:458156 to 458992 | ORF Map | GBrowse

	View Computational GO annotations for CKB1
Molecular Function
Manually curated	protein kinase regulator activity (IMP, IPI) protein serine/threonine kinase inhibitor activity (IDA)
Biological Process
Manually curated	protein phosphorylation (IDA, IMP) regulation of transcription from RNA polymerase I promoter (IDA) regulation of transcription from RNA polymerase III promoter (IDA) response to DNA damage stimulus (IDA)
Cellular Component
Manually curated	protein kinase CK2 complex (IDA) UTP-C complex (IDA)

Classical genetics
null	ionic stress resistance: decreased toxin resistance: increased
Large-scale survey
null	competitive fitness: decreased hyperosmotic stress resistance: decreased lipid particle morphology: abnormal resistance to calcium dichloride: decreased resistance to methyl methanesulfonate: decreased resistance to dihydromotuporamine C: decreased resistance to ethanol: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to sulfanilamide: decreased resistance to sodium arsenite: increased resistance to cycloheximide: decreased resistance to paromomycin: decreased resistance to dimethyl sulfoxide: decreased resistance to sodium selenide: decreased resistance to caffeine: decreased resistance to doxorubicin: decreased sporulation: decreased stress resistance: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	472 total interaction(s) for 284 unique genes/features.
Physical Interactions	Affinity Capture-MS: 105 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Biochemical Activity: 8 Co-purification: 1 PCA: 4 Reconstituted Complex: 11 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 3 Negative Genetic: 238 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 62 Synthetic Growth Defect: 21 Synthetic Lethality: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:458156 to 458992 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..837 458156..458992 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002987