CKB1/YGL019W Summary Help

Standard Name CKB1
Systematic Name YGL019W
Feature Type ORF, Verified
Description Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases (1, 2)
Name Description Casein Kinase Beta subunit
Gene Product Alias CK2 subunit 3
Chromosomal Location
ChrVII:458156 to 458992 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CKB1 GO evidence and references
  View Computational GO annotations for CKB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 64 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
478 total interaction(s) for 283 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 107
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 6
  • Biochemical Activity: 9
  • Co-purification: 1
  • PCA: 4
  • Reconstituted Complex: 11
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 3
  • Negative Genetic: 239
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 1
  • Positive Genetic: 62
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 278
Molecular Weight (Da) 32,265
Isoelectric Point (pI) 4.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:458156 to 458992 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..837 458156..458992 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002987
References cited on this page View Complete Literature Guide for CKB1
1) Ackermann K, et al.  (2001) Genes targeted by protein kinase CK2: a genome-wide expression array analysis in yeast. Mol Cell Biochem 227(1-2):59-66
2) Ahmed K, et al.  (2002) Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biol 12(5):226-30
3) Bidwai AP, et al.  (1995) Cloning and disruption of CKB1, the gene encoding the 38-kDa beta subunit of Saccharomyces cerevisiae casein kinase II (CKII). Deletion of CKII regulatory subunits elicits a salt-sensitive phenotype. J Biol Chem 270(18):10395-404