CKA2/YOR061W Summary

CKA2 BASIC INFORMATION

Standard Name	CKA2
Systematic Name	YOR061W
Alias	YOR29-12
Feature Type	ORF, Verified
Description	Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases (1, 2, 3)
Name Description	Casein Kinase Alpha' subunit

GO Annotations	All CKA2 GO evidence and references
	View Computational GO annotations for CKA2
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA)
Biological Process
Manually curated	cellular ion homeostasis (IPI) establishment of cell polarity (IPI) flocculation via cell wall protein-carbohydrate interaction (IMP) G1/S transition of mitotic cell cycle (IMP) G2/M transition of mitotic cell cycle (IMP) protein amino acid phosphorylation (IDA) regulation of transcription from RNA polymerase I promoter (IDA) regulation of transcription from RNA polymerase III promoter (IDA) response to DNA damage stimulus (IDA)
Cellular Component
Manually curated	protein kinase CK2 complex (IDA) UTP-C complex (IDA)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 377 )

Mutant Phenotype	All CKA2 Phenotype details and references
Classical genetics
null	ionic stress resistance: decreased resistance to benomyl: increased
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: decreased resistance to rapamycin: decreased resistance to wortmannin: increased resistance to caspofungin: increased resistance to fluconazole: increased toxin resistance: increased viable

Interactions	CKA2 All interactions details and references
	235 total interaction(s) for 147 unique genes/features.
Physical Interactions	Affinity Capture-MS: 98 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Biochemical Activity: 15 Co-purification: 1 PCA: 2 Reconstituted Complex: 2 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 7 Phenotypic Enhancement: 32 Phenotypic Suppression: 61 Synthetic Growth Defect: 4 Synthetic Lethality: 2 Synthetic Rescue: 1

Sequence Information

ChrXV:441536 to 442555 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1020	441536..442555	2006-01-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005587

CKA2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CKA2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CKA2]

1)	Padmanabha R, et al. (1990) Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae. Mol Cell Biol 10(8):4089-99
2)	Ackermann K, et al. (2001) Genes targeted by protein kinase CK2: a genome-wide expression array analysis in yeast. Mol Cell Biochem 227(1-2):59-66
3)	Ahmed K, et al. (2002) Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biol 12(5):226-30

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