Standard Name	CKA2
Systematic Name	YOR061W
Alias	YOR29-12
Feature Type	ORF, Verified
Description	Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching (1, 2, 3, 4, 5)
Name Description	Casein Kinase Alpha' subunit
Gene Product Alias	CK2 subunit 1

Chromosomal Location	ChrXV:441534 to 442553 | ORF Map | GBrowse

	View Computational GO annotations for CKA2
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA)
Biological Process
Manually curated	chronological cell aging (IMP) donor selection (IGI) protein phosphorylation (IDA) regulation of transcription from RNA polymerase I promoter (IDA) regulation of transcription from RNA polymerase III promoter (IDA) response to DNA damage stimulus (IDA)
Cellular Component
Manually curated	protein kinase CK2 complex (IDA) UTP-C complex (IDA)

Regulatory modules	predicted: cellcycle (377)

Classical genetics
null	ionic stress resistance: decreased resistance to benomyl: increased toxin resistance: increased
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: decreased haploproficient resistance to sirolimus: decreased resistance to neothyonidioside: decreased resistance to benzo[a]pyrene: decreased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to caspofungin: increased resistance to wortmannin: increased resistance to hydroxyurea: decreased resistance to bleomycin: decreased resistance to tunicamycin: increased stress resistance: increased toxin resistance: decreased toxin resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	422 total interaction(s) for 275 unique genes/features.
Physical Interactions	Affinity Capture-MS: 162 Affinity Capture-RNA: 2 Affinity Capture-Western: 11 Biochemical Activity: 28 Co-purification: 1 PCA: 6 Reconstituted Complex: 3 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 7 Dosage Lethality: 1 Dosage Rescue: 9 Negative Genetic: 81 Phenotypic Enhancement: 7 Phenotypic Suppression: 16 Positive Genetic: 72 Synthetic Growth Defect: 7 Synthetic Lethality: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:441534 to 442553 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1020 441534..442553 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005587