CKA1/YIL035C Summary

CKA1 BASIC INFORMATION

Standard Name	CKA1
Systematic Name	YIL035C
Feature Type	ORF, Verified
Description	Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases (1, 2, 3, 4)
Name Description	Casein Kinase Alpha subunit

GO Annotations	All CKA1 GO evidence and references
	View Computational GO annotations for CKA1
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA)
Biological Process
Manually curated	cellular ion homeostasis (IPI) establishment of cell polarity (IMP) flocculation via cell wall protein-carbohydrate interaction (IMP) G1/S transition of mitotic cell cycle (IPI) G2/M transition of mitotic cell cycle (IPI) protein amino acid phosphorylation (IDA) regulation of transcription from RNA polymerase I promoter (IDA) regulation of transcription from RNA polymerase III promoter (IDA) response to DNA damage stimulus (IDA)
Cellular Component
Manually curated	protein kinase CK2 complex (IDA) UTP-C complex (IDA)

Regulatory Role
Regulatory modules	predicted: stressResponse ( 487 )

Mutant Phenotype	All CKA1 Phenotype details and references
Classical genetics
null	ionic stress resistance: decreased
unspecified	transposable element transposition: decreased
Large-scale survey
null	resistance to citric acid: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyrimidine: decreased viable

Interactions	CKA1 All interactions details and references
	266 total interaction(s) for 169 unique genes/features.
Physical Interactions	Affinity Capture-MS: 169 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 27 Co-purification: 3 PCA: 1 Reconstituted Complex: 4 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 5 Phenotypic Enhancement: 35 Phenotypic Suppression: 9 Synthetic Growth Defect: 3 Synthetic Lethality: 2 Synthetic Rescue: 2

Sequence Information

ChrIX:288907 to 287789 | |

Note: this feature is encoded on the Crick strand.

Genetic position: -29 cM

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1119	288907..287789	1994-12-10	1994-12-10

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001297

CKA1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CKA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CKA1]

1)	Chen-Wu JL, et al. (1988) Isolation, sequencing, and disruption of the CKA1 gene encoding the alpha subunit of yeast casein kinase II. Mol Cell Biol 8(11):4981-90
2)	Marin O, et al. (1999) Tyrosine versus serine/threonine phosphorylation by protein kinase casein kinase-2. A study with peptide substrates derived from immunophilin Fpr3. J Biol Chem 274(41):29260-5
3)	Ackermann K, et al. (2001) Genes targeted by protein kinase CK2: a genome-wide expression array analysis in yeast. Mol Cell Biochem 227(1-2):59-66
4)	Ahmed K, et al. (2002) Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biol 12(5):226-30

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