CIK1/YMR198W Summary Help

Standard Name CIK1 1
Systematic Name YMR198W
Feature Type ORF, Verified
Description Kinesin-associated protein; required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; CIK1 has a paralog, VIK1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7)
Name Description Chromosome Instability and Karyogamy 1
Chromosomal Location
ChrXIII:659745 to 661529 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CIK1 GO evidence and references
  View Computational GO annotations for CIK1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All CIK1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
overexpression
Resources
interactions All CIK1 Interaction evidence and references
760 total interaction(s) for 459 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 31
Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Lethality: 1
  • Dosage Rescue: 7
  • Negative Genetic: 519
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 1
  • Positive Genetic: 103
  • Synthetic Growth Defect: 30
  • Synthetic Lethality: 53
  • Synthetic Rescue: 1
Resources
Expression Summary
histogram
Resources
Protein Information All CIK1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:659745 to 661529 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1785 659745..661529 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004811
References cited on this page View Complete Literature Guide for CIK1
1) Page BD and Snyder M  (1992) CIK1: a developmentally regulated spindle pole body-associated protein important for microtubule functions in Saccharomyces cerevisiae. Genes Dev 6(8):1414-29
2) Barrett JG, et al.  (2000) The Kar3p kinesin-related protein forms a novel heterodimeric structure with its associated protein Cik1p. Mol Biol Cell 11(7):2373-85
3) Page BD, et al.  (1994) Localization of the Kar3 kinesin heavy chain-related protein requires the Cik1 interacting protein. J Cell Biol 124(4):507-19
4) Manning BD and Snyder M  (2000) Drivers and passengers wanted! the role of kinesin-associated proteins. Trends Cell Biol 10(7):281-9
5) Cottingham FR, et al.  (1999) Novel roles for saccharomyces cerevisiae mitotic spindle motors. J Cell Biol 147(2):335-50
6) Shanks RM, et al.  (2001) The Kar3-interacting protein Cik1p plays a critical role in passage through meiosis I in Saccharomyces cerevisiae. Genetics 159(3):939-51
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61