CIC1/YHR052W Summary Help

Standard Name CIC1 1
Systematic Name YHR052W
Alias NSA3 2
Feature Type ORF, Verified
Description Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles (1, 2, 3)
Name Description Core Interacting Component 1
Chromosomal Location
ChrVIII:210848 to 211978 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CIC1 GO evidence and references
  View Computational GO annotations for CIC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 93 genes
Resources
Large-scale survey
conditional
overexpression
Resources
302 total interaction(s) for 140 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 264
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 14
  • Co-fractionation: 3
  • Co-purification: 4
  • PCA: 9
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 376
Molecular Weight (Da) 42,529
Isoelectric Point (pI) 9.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:210848 to 211978 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1131 210848..211978 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001094
References cited on this page View Complete Literature Guide for CIC1
1) Jager S, et al.  (2001) Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4. EMBO J 20(16):4423-31
2) Harnpicharnchai P, et al.  (2001) Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8(3):505-15
3) Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27