CIA2/YHR122W Summary Help

Standard Name CIA2 1, 2
Systematic Name YHR122W
Feature Type ORF, Verified
Description Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B (2)
Name Description Cytosolic Iron-sulfur protein Assembly 1
Chromosomal Location
ChrVIII:353625 to 354320 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CIA2 GO evidence and references
  View Computational GO annotations for CIA2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Classical genetics
conditional
Large-scale survey
conditional
null
Resources
18 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • PCA: 1
  • Two-hybrid: 4

Genetic Interactions
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 231
Molecular Weight (Da) 25,675
Isoelectric Point (pI) 4.39
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:353625 to 354320 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..696 353625..354320 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001164
References cited on this page View Complete Literature Guide for CIA2
1) Mascarenhas J and Lill R  (2011) Cia2 is essential for iron-sulfur cluster insertion ()
2) Stehling O, et al.  (2012) MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science 337(6091):195-9