Standard Name	CHZ1 1
Systematic Name	YER030W
Feature Type	ORF, Verified
Description	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description	Chaperone for Htz1/H2A-H2B dimer 1

Chromosomal Location	ChrV:213437 to 213898 | ORF Map | GBrowse

	View Computational GO annotations for CHZ1
Molecular Function
Manually curated	histone binding (IPI)
Biological Process
Manually curated	chromatin remodeling (IPI)
Cellular Component
Manually curated	nucleus (IDA)
High-throughput	nucleus (IDA)

Large-scale survey
null	UV resistance: decreased competitive fitness: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	47 total interaction(s) for 36 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 4 Affinity Capture-Western: 5 Biochemical Activity: 1 Co-crystal Structure: 4 Co-localization: 2
Genetic Interactions	Negative Genetic: 17 Positive Genetic: 2 Synthetic Growth Defect: 4 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:213437 to 213898 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2005-11-29
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..462 213437..213898 2011-02-03 2005-11-29
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000832