CHS6/YJL099W Summary Help

Standard Name CHS6 1
Systematic Name YJL099W
Alias CSD3
Feature Type ORF, Verified
Description Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; primary component of the Chs5/6 complex that binds directly to membranes; CHS6 has a paralog, BCH2, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7)
Name Description CHitin Synthase-related 1
Chromosomal Location
ChrX:239414 to 241654 | ORF Map | GBrowse
Gene Ontology Annotations All CHS6 GO evidence and references
  View Computational GO annotations for CHS6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
reduction of function
Large-scale survey
222 total interaction(s) for 119 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 9
  • Co-crystal Structure: 1
  • Co-purification: 3
  • Reconstituted Complex: 5
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 102
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 3
  • Positive Genetic: 1
  • Synthetic Growth Defect: 24
  • Synthetic Lethality: 45
  • Synthetic Rescue: 11

Expression Summary
Length (a.a.) 746
Molecular Weight (Da) 86,041
Isoelectric Point (pI) 5.86
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:239414 to 241654 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2241 239414..241654 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003635
References cited on this page View Complete Literature Guide for CHS6
1) Cid VJ, et al.  (1995) Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae. Microbiol Rev 59(3):345-86
2) Ziman M, et al.  (1998) Chs6p-dependent anterograde transport of Chs3p from the chitosome to the plasma membrane in Saccharomyces cerevisiae. Mol Biol Cell 9(6):1565-76
3) Bulawa CE  (1992) CSD2, CSD3, and CSD4, genes required for chitin synthesis in Saccharomyces cerevisiae: the CSD2 gene product is related to chitin synthases and to developmentally regulated proteins in Rhizobium species and Xenopus laevis. Mol Cell Biol 12(4):1764-76
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Trautwein M, et al.  (2006) Arf1p, Chs5p and the ChAPs are required for export of specialized cargo from the Golgi. EMBO J 25(5):943-54
6) Wang CW, et al.  (2006) Exomer: A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. J Cell Biol 174(7):973-83
7) Paczkowski JE, et al.  (2012) The exomer cargo adaptor structure reveals a novel GTPase-binding domain. EMBO J 31(21):4191-203