CHO1/YER026C Summary Help

Standard Name CHO1 1
Systematic Name YER026C
Alias PSS1
Feature Type ORF, Verified
Description Phosphatidylserine synthase; functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline (1, 2, 3, 4, 5)
Name Description CHOline requiring 3
Chromosomal Location
ChrV:208474 to 207644 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 22 cM
Gene Ontology Annotations All CHO1 GO evidence and references
  View Computational GO annotations for CHO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Pathways
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
repressible
Resources
45 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • PCA: 18
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 6
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 2
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 276
Molecular Weight (Da) 30,804
Isoelectric Point (pI) 6.23
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:208474 to 207644 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 22 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..831 208474..207644 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000828
References cited on this page View Complete Literature Guide for CHO1
1) Letts VA, et al.  (1983) Isolation of the yeast structural gene for the membrane-associated enzyme phosphatidylserine synthase. Proc Natl Acad Sci U S A 80(23):7279-83
2) Yamashita S and Nikawa J  (1997) Phosphatidylserine synthase from yeast. Biochim Biophys Acta 1348(1-2):228-35
3) Atkinson KD, et al.  (1980) Yeast mutants auxotrophic for choline or ethanolamine. J Bacteriol 141(2):558-64
4) Paltauf F, et al.  (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
5) Bae-Lee MS and Carman GM  (1984) Phosphatidylserine synthesis in Saccharomyces cerevisiae. Purification and characterization of membrane-associated phosphatidylserine synthase. J Biol Chem 259(17):10857-62