Standard Name	CHK1 1
Systematic Name	YBR274W
Feature Type	ORF, Verified
Description	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase (1, 2, 3, 4, 5)
Name Description	CHeckpoint Kinase 1, 6

Chromosomal Location	ChrII:749594 to 751177 | ORF Map | GBrowse

	View Computational GO annotations for CHK1
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA)
Biological Process
Manually curated	DNA damage checkpoint (IMP) protein phosphorylation (IDA) replication fork protection (IGI)
Cellular Component
Manually curated	nucleus (IPI)

Classical genetics
null	apoptosis: decreased cell cycle progression through the G2/M phase transition: normal cell cycle progression through the G2/M phase transition: abnormal chromosome/plasmid maintenance: abnormal mutation frequency: increased nuclear position: abnormal resistance to selenomethionine: decreased resistance to selenite(2-): decreased resistance to 4-aminofolic acid: increased
Large-scale survey
null	competitive fitness: increased resistance to St. John's Wort extract: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	260 total interaction(s) for 193 unique genes/features.
Physical Interactions	Affinity Capture-MS: 24 Affinity Capture-Western: 2 Biochemical Activity: 3 Reconstituted Complex: 17 Two-hybrid: 8
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 125 Phenotypic Enhancement: 23 Phenotypic Suppression: 3 Positive Genetic: 17 Synthetic Growth Defect: 16 Synthetic Lethality: 7 Synthetic Rescue: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:749594 to 751177 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1584 749594..751177 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000478