CHD1/YER164W Summary

CHD1 BASIC INFORMATION

Standard Name	CHD1 1
Systematic Name	YER164W
Feature Type	ORF, Verified
Description	Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes (1, 2, 3, 4)
Name Description	Chromatin organization modifier, Helicase, and DNA-binding domains 1

GO Annotations	All CHD1 GO evidence and references
	View Computational GO annotations for CHD1
Molecular Function
Manually curated	ATPase activity (IDA) RNA polymerase II transcription elongation factor activity (IPI)
Biological Process
Manually curated	chromatin remodeling (IDA) nucleosome positioning (IDA) positive regulation of transcription from RNA polymerase II promoter (IMP) RNA elongation from RNA polymerase II promoter (IPI)
Cellular Component
Manually curated	SAGA complex (IDA) SLIK (SAGA-like) complex (IDA) transcription elongation factor complex (IPI)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All CHD1 Phenotype details and references
Classical genetics
null	heat sensitivity: normal viable
Large-scale survey
null	viable

Interactions	CHD1 All interactions details and references
	272 total interaction(s) for 176 unique genes/features.
Physical Interactions	Affinity Capture-MS: 84 Affinity Capture-Western: 6 Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 64 Phenotypic Suppression: 78 Synthetic Growth Defect: 21 Synthetic Lethality: 5 Synthetic Rescue: 11

Sequence Information

ChrV:505387 to 509793 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4407	505387..509793	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000966

CHD1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CHD1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CHD1]

1)	Woodage T, et al. (1997) Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A 94(21):11472-7
2)	Tran HG, et al. (2000) The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor. EMBO J 19(10):2323-31
3)	Simic R, et al. (2003) Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes. EMBO J 22(8):1846-56
4)	Pray-Grant MG, et al. (2005) Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature 433(7024):434-8

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