CHD1/YER164W Summary Help

Standard Name CHD1 1
Systematic Name YER164W
Feature Type ORF, Verified
Description Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes (1, 2, 3, 4, 5)
Name Description Chromatin organization modifier, Helicase, and DNA-binding domains 1
Chromosomal Location
ChrV:505392 to 509798 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CHD1 GO evidence and references
  View Computational GO annotations for CHD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
unspecified
Resources
361 total interaction(s) for 227 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 96
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 6
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 105
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 7
  • Positive Genetic: 78
  • Synthetic Growth Defect: 34
  • Synthetic Lethality: 7
  • Synthetic Rescue: 14

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,468
Molecular Weight (Da) 168,240
Isoelectric Point (pI) 6.47
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:505392 to 509798 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..4407 505392..509798 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000966
References cited on this page View Complete Literature Guide for CHD1
1) Woodage T, et al.  (1997) Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A 94(21):11472-7
2) Tran HG, et al.  (2000) The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor. EMBO J 19(10):2323-31
3) Simic R, et al.  (2003) Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes. EMBO J 22(8):1846-56
4) Pray-Grant MG, et al.  (2005) Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature 433(7024):434-8
5) Smolle M, et al.  (2012) Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange. Nat Struct Mol Biol 19(9):884-92