Standard Name	CHC1 1
Systematic Name	YGL206C
Alias	SWA5 2
Feature Type	ORF, Verified
Description	Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function (1, 3, 4)
Name Description	Clathrin Heavy Chain 1

Chromosomal Location	ChrVII:107504 to 102543 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -133 cM

	View Computational GO annotations for CHC1
Molecular Function
Manually curated	structural molecule activity (TAS)
Biological Process
Manually curated	endocytosis (IDA, IMP) vesicle-mediated transport (TAS)
Cellular Component
Manually curated	clathrin vesicle coat (TAS)

Classical genetics
conditional	Wsc1p-GFP distribution: abnormal
null	acid pH resistance: decreased alkaline pH resistance: decreased glutathione accumulation: increased ionic stress resistance: decreased metal resistance: decreased alpha-factor secretion: decreased carboxypeptidase Y (Prc1p) modification: decreased resistance to sirolimus: decreased resistance to caffeine: decreased resistance to monensin: decreased toxin resistance: decreased
Large-scale survey
null	acid pH resistance: decreased dessication resistance: decreased lipid particle morphology: abnormal metal resistance: decreased resistance to hydroxyurea: decreased resistance to monensin: decreased resistance to caspofungin: decreased resistance to sulfanilamide: decreased resistance to gentamycin C1: decreased resistance to methanol: decreased resistance to hygromycin B: decreased resistance to (S)-lactic acid: decreased resistance to acetic acid: decreased resistance to hydrogen chloride: decreased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to boric acid: decreased resistance to dimethyl sulfoxide: decreased resistance to amiodarone: decreased resistance to L-1,4-dithiothreitol: decreased resistance to sorbate: decreased respiratory growth: absent transposable element transposition: decreased utilization of nitrogen source: absent vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	157 total interaction(s) for 92 unique genes/features.
Physical Interactions	Affinity Capture-MS: 45 Affinity Capture-RNA: 2 Affinity Capture-Western: 25 Co-localization: 7 PCA: 11 Reconstituted Complex: 7 Two-hybrid: 3
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 10 Negative Genetic: 4 Phenotypic Enhancement: 7 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 23 Synthetic Lethality: 9 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:107504 to 102543 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -133 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4962 107504..102543 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003174