CHA4/YLR098C Summary

CHA4 BASIC INFORMATION

Standard Name	CHA4 1
Systematic Name	YLR098C
Alias	SIL2 2 , SIL3 2
Feature Type	ORF, Verified
Description	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain (1, 3)
Name Description	Catabolism of Hydroxy Amino acids 1, 4

GO Annotations	All CHA4 GO evidence and references
	View Computational GO annotations for CHA4
Molecular Function
Manually curated	transcription factor activity (IDA, IPI, ISS)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	cellular amino acid catabolic process (IGI, IMP) regulation of transcription, DNA-dependent (IMP)
Cellular Component
Manually curated	nucleus (IPI)

Mutant Phenotype	All CHA4 Phenotype details and references
Large-scale survey
null	viable

Interactions	CHA4 All interactions details and references
	22 total interaction(s) for 20 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Biochemical Activity: 5 Two-hybrid: 12
Genetic Interactions	Phenotypic Enhancement: 2 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrXII:339474 to 337528 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1947	339474..337528	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004088

CHA4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CHA4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CHA4]

1)	Holmberg S and Schjerling P (1996) Cha4p of Saccharomyces cerevisiae activates transcription via serine/threonine response elements. Genetics 144(2):467-78
2)	Pedersen JO, et al. (1997) Locus-specific suppression of ilv1 in Saccharomyces cerevisiae by deregulation of CHA1 transcription. Mol Gen Genet 255(6):561-9
3)	Schjerling P and Holmberg S (1996) Comparative amino acid sequence analysis of the C6 zinc cluster family of transcriptional regulators. Nucleic Acids Res 24(23):4599-607
4)	Petersen JG, et al. (1988) Molecular genetics of serine and threonine catabolism in Saccharomyces cerevisiae. Genetics 119(3):527-34

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