CDS1/YBR029C Summary

CDS1 BASIC INFORMATION

Standard Name	CDS1
Systematic Name	YBR029C
Alias	CDG1
Feature Type	ORF, Verified
Description	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids (1, 2)
Name Description	CDP-Diacylglycerol Synthase 2

GO Annotations	All CDS1 GO evidence and references
	View Computational GO annotations for CDS1
Molecular Function
Manually curated	phosphatidate cytidylyltransferase activity (IDA)
Biological Process
Manually curated	phosphatidylglycerol biosynthetic process (TAS) phosphatidylserine metabolic process (TAS)
Cellular Component
Manually curated	endoplasmic reticulum (TAS) mitochondrion (TAS)

Pathways	CDP-diacylglycerol biosynthesis phosphatidic acid and phospholipid biosynthesis

Mutant Phenotype	All CDS1 Phenotype details and references
Classical genetics
null	endoplasmic reticulum morphology: abnormal
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
overexpression	vegetative growth: decreased

Interactions	CDS1 All interactions details and references
	7 total interaction(s) for 7 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Protein-RNA: 1 Two-hybrid: 3
Genetic Interactions	Synthetic Lethality: 2

Sequence Information

ChrII:297742 to 296369 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-16 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1374	297742..296369	2004-07-16	1997-01-28

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000233

CDS1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CDS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDS1]

1)	Shen H and Dowhan W (1997) Regulation of phospholipid biosynthetic enzymes by the level of CDP-diacylglycerol synthase activity. J Biol Chem 272(17):11215-20
2)	Shen H, et al. (1996) The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth. J Biol Chem 271(2):789-95

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