CDC55/YGL190C Summary Help

CDC55 BASIC INFORMATION

Standard Name CDC55 1
Systematic Name YGL190C
Feature Type ORF, Verified
Description Non-essential regulatory subunit B of protein phosphatase 2A (PP2A), which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at bud neck and bud tip (2, 3, 4, 5)
Name Description Cell Division Cycle
GO Annotations All CDC55 GO evidence and references
    View Computational GO annotations for CDC55
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: cellcycle ( 263 )
Mutant Phenotype All CDC55 Phenotype details and references
Classical genetics
conditional
null
unspecified
Large-scale survey
null
Interactions CDC55 All interactions details and references
214 total interaction(s) for 164 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 55
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 11
  • Biochemical Activity: 3
  • Protein-RNA: 1
  • Two-hybrid: 14
Genetic Interactions
  • Dosage Lethality: 4
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 46
  • Phenotypic Suppression: 54
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 5
  • Synthetic Rescue: 10
Sequence Information
ChrVII:147395 to 145815 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -125 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1581 147395..145815 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003158

CDC55 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for CDC55

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC55]

1) Healy AM, et al.  (1991) CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase. Mol Cell Biol 11(11):5767-80
2) Jiang Y and Broach JR  (1999) Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J 18(10):2782-92
3) Wang Y and Burke DJ  (1997) Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol Cell Biol 17(2):620-6
4) Gentry MS and Hallberg RL  (2002) Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle. Mol Biol Cell 13(10):3477-92
5) Queralt E, et al.  (2006) Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast. Cell 125(4):719-32