CDC5/YMR001C Summary Help

Standard Name CDC5 1
Systematic Name YMR001C
Alias MSD2 2 , PKX2
Feature Type ORF, Verified
Description Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rholp guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate (3, 4, 5, 6, 7, 8)
Name Description Cell Division Cycle 9
Chromosomal Location
ChrXIII:271136 to 269019 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -14 cM
Gene Ontology Annotations All CDC5 GO evidence and references
  View Computational GO annotations for CDC5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Classical genetics
reduction of function
Large-scale survey
reduction of function
349 total interaction(s) for 171 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 62
  • Affinity Capture-Western: 33
  • Biochemical Activity: 46
  • Co-localization: 7
  • Co-purification: 2
  • Protein-peptide: 2
  • Reconstituted Complex: 9
  • Two-hybrid: 22

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 13
  • Dosage Rescue: 34
  • Negative Genetic: 13
  • Phenotypic Enhancement: 14
  • Phenotypic Suppression: 21
  • Positive Genetic: 7
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 19
  • Synthetic Rescue: 34

Expression Summary
Length (a.a.) 705
Molecular Weight (Da) 81,030
Isoelectric Point (pI) 9.64
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXIII:271136 to 269019 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -14 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2118 271136..269019 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004603
References cited on this page View Complete Literature Guide for CDC5
1) Hartwell LH, et al.  (1973) Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants. Genetics 74(2):267-286
2) Kitada K, et al.  (1993) A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. Mol Cell Biol 13(7):4445-57
3) Hu F and Elledge SJ  (2002) Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle 1(5):351-5
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
5) Alexandru G, et al.  (2001) Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell 105(4):459-72
6) Yoshida S, et al.  (2006) Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science 313(5783):108-11
7) Snead JL, et al.  (2007) A Coupled Chemical-Genetic and Bioinformatic Approach to Polo-like Kinase Pathway Exploration. Chem Biol 14(11):1261-72
8) Iacovella MG, et al.  (2010) Analysis of Polo-like kinase Cdc5 in the meiosis recombination checkpoint. Cell Cycle 9(6):1182-93
9) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9