Standard Name	CDC48 1
Systematic Name	YDL126C
Feature Type	ORF, Verified
Description	AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP (2, 3, 4, 5, 6, 7, 8, 9, 10)
Name Description	Cell Division Cycle 1

Chromosomal Location	ChrIV:238664 to 236157 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CDC48
Molecular Function
Manually curated	ATPase activity (IDA) ubiquitin binding (IDA)
Biological Process
Manually curated	cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process (IMP) endoplasmic reticulum membrane fusion (IMP) ER-associated misfolded protein catabolic process (IMP) ER-associated protein catabolic process (IMP) macroautophagy (IMP) mitochondria-associated protein catabolic process (IMP) mitotic spindle disassembly (IMP) nucleus-associated proteasomal ubiquitin-dependent protein catabolic process (IMP) piecemeal microautophagy of nucleus (IMP) positive regulation of protein localization to nucleus (IMP) proteasomal ubiquitin-dependent protein catabolic process (IMP) retrograde protein transport, ER to cytosol (IMP) ribophagy (IMP) sister chromatid biorientation (IMP)
Cellular Component
Manually curated	Cdc48p-Npl4p-Ufd1p AAA ATPase complex (IDA) Cdc48p-Npl4p-Vms1p AAA ATPase complex (IDA) cytosol (IDA) Doa10p ubiquitin ligase complex (IDA) endoplasmic reticulum membrane (IDA) colocalizes_with mitochondrion (IDA) nucleus (IDA)
High-throughput	mating projection tip (IDA)

Classical genetics
conditional	autophagy: decreased cell cycle progression: arrested cell cycle progression: abnormal cell cycle progression in G1 phase: delayed cell cycle progression in M phase: arrested cellular morphology: abnormal cold sensitivity: increased Ura3p-CL1 accumulation: increased Rpo21p accumulation: increased CPY* accumulation: increased 6Myc-Hmg2p accumulation: increased Cdc5p accumulation: increased Myc-Ase1p accumulation: increased Fbp1p accumulation: increased Ufd1p distribution: increased duration myc-Spt23p distribution: abnormal GFP-Spt23p distribution: abnormal CPY* distribution: abnormal GFP-Mga2p modification: decreased Slt2p modification: increased resistance to Congo Red: decreased resistance to Calcofluor White: decreased spindle morphology: abnormal toxin resistance: decreased
overexpression	budding: abnormal cell cycle progression in G2 phase: abnormal toxin resistance: increased
reduction of function	mitochondrial morphology: abnormal oxidative stress resistance: decreased Fzo1p accumulation: increased vegetative growth: decreased rate
repressible	CPY* accumulation: increased vegetative growth: decreased
Large-scale survey
conditional	colony sectoring: increased
null	inviable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
reduction of function	competitive fitness: increased
repressible	cell cycle progression in G2 phase: abnormal chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	466 total interaction(s) for 257 unique genes/features.
Physical Interactions	Affinity Capture-MS: 141 Affinity Capture-RNA: 4 Affinity Capture-Western: 98 Biochemical Activity: 1 Co-purification: 2 Protein-peptide: 2 Reconstituted Complex: 11 Two-hybrid: 29
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 29 Negative Genetic: 99 Phenotypic Enhancement: 2 Phenotypic Suppression: 7 Positive Genetic: 24 Synthetic Growth Defect: 9 Synthetic Lethality: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:238664 to 236157 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2508 238664..236157 2004-02-11 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002284