CDC48/YDL126C Summary

CDC48 BASIC INFORMATION

Standard Name	CDC48 1
Systematic Name	YDL126C
Feature Type	ORF, Verified
Description	ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome (2)
Name Description	Cell Division Cycle 1

GO Annotations	All CDC48 GO evidence and references
	View Computational GO annotations for CDC48
Molecular Function
Manually curated	ATPase activity (IDA)
Biological Process
Manually curated	apoptosis (TAS) ER-associated protein catabolic process (IMP) mitotic cell cycle (IMP) protein transport (IDA) ubiquitin-dependent protein catabolic process (IDA, IPI) vesicle fusion (IDA)
Cellular Component
Manually curated	Cdc48p-Npl4p-Ufd1p AAA ATPase complex (IDA) cytosol (IDA) Doa10p ubiquitin ligase complex (IDA) endoplasmic reticulum membrane (IDA) microsome (IDA) nucleus (IDA)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All CDC48 Phenotype details and references
Classical genetics
conditional	cell cycle progression: arrested cellular morphology: abnormal cold sensitivity: increased Ura3p-CL1 accumulation: increased toxin resistance: decreased
overexpression	budding: abnormal cell cycle progression in G2 phase: abnormal toxin resistance: increased
reduction of function	oxidative stress resistance: decreased
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased
repressible	cell cycle progression in G2 phase: abnormal

Interactions	CDC48 All interactions details and references
	188 total interaction(s) for 73 unique genes/features.
Physical Interactions	Affinity Capture-MS: 83 Affinity Capture-RNA: 1 Affinity Capture-Western: 48 Biochemical Activity: 1 Co-purification: 2 Reconstituted Complex: 13 Two-hybrid: 26
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 3 Phenotypic Enhancement: 1 Phenotypic Suppression: 3 Synthetic Growth Defect: 3 Synthetic Lethality: 3

Sequence Information

ChrIV:238664 to 236157 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-02-11 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2508	238664..236157	2004-02-11	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002284

CDC48 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CDC48

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC48]

1)	Moir D, et al. (1982) Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics 100(4):547-63
2)	Ye Y, et al. (2003) Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol 162(1):71-84

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.