Standard Name	CDC45 1
Systematic Name	YLR103C
Alias	SLD4 2
Feature Type	ORF, Verified
Description	DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes (3, 4)
Name Description	Cell Division Cycle 1

Chromosomal Location	ChrXII:345941 to 343989 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CDC45
Molecular Function
Manually curated	chromatin binding (IDA) DNA replication origin binding (IDA)
Biological Process
Manually curated	DNA replication initiation (IGI, IMP) double-strand break repair via break-induced replication (IMP) pre-replicative complex assembly (IPI) regulation of chromatin silencing at telomere (IMP) S phase of mitotic cell cycle (IGI, IMP)
Cellular Component
Manually curated	DNA replication preinitiation complex (IDA) nuclear replication fork (IDA) nucleus (IDA) pre-replicative complex (IDA) replication fork protection complex (IDA)

Classical genetics
conditional	cell cycle progression: arrested cell cycle progression in S phase: arrested chromosome segregation: abnormal cold sensitivity: increased mitotic recombination: increased
null	inviable
repressible	chromosome/plasmid maintenance: decreased
Large-scale survey
conditional	colony sectoring: increased
null	haploproficient inviable
reduction of function	competitive fitness: increased
repressible	cell cycle progression in S phase: abnormal chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	251 total interaction(s) for 139 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-Western: 41 Co-fractionation: 9 Co-localization: 3 Protein-peptide: 1 Reconstituted Complex: 14 Two-hybrid: 6
Genetic Interactions	Dosage Growth Defect: 5 Dosage Lethality: 1 Dosage Rescue: 5 Negative Genetic: 25 Phenotypic Enhancement: 5 Phenotypic Suppression: 2 Positive Genetic: 1 Synthetic Growth Defect: 39 Synthetic Lethality: 76
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:345941 to 343989 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1953 345941..343989 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004093