CDC42/YLR229C Summary 
| Standard Name | CDC42 |
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| Systematic Name | YLR229C |
| Feature Type | ORF, Verified |
| Description | Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins (1 and see Summary Paragraph) |
| Name Description | Cell Division Cycle |
| Chromosomal Location | |
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| Note: this feature is encoded on the Crick strand. | |
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| Genetic position: 165 cM |
| View Computational GO annotations for CDC42 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated |
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| Cellular Component | |
| Manually curated |
| Regulatory modules | predicted: stressResponse (367) |
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| Classical genetics | |
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| conditional | |
| Large-scale survey | |
| conditional | |
| null | |
| overexpression | |
| reduction of function | |
| repressible | |
| Resources |
| 423 total interaction(s) for 180 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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| Resources |
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Genetic position: 165 cM | |||||||||||||
| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000004219 |
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CDC42 is an essential gene that encodes a small GTPase in the Rho/Rac subfamily of Ras-like GTPases (2, 3, 4). Other S. cerevisiae Rho GTPases are encoded by RHO1, RHO2, RHO3, RHO4, and RHO5 (3). Like other eukaryotic Rho-type GTPases, Cdc42p is involved in the establishment of cell polarity; its downstream effects include reorganization of the actin cytoskeleton and protein kinase-dependent induction of transcription (3, 4). Cdc42p is localized to the plasma membrane at sites of growth such as incipient bud sites, bud tips, the bud neck during cytokinesis, and shmoo tips of mating cells (5). At the restrictive temperature, temperature-sensitive cdc42 mutants fail to bud but continue to grow, and then arrest as large, unbudded cells (6). The GTPase activity of Cdc42p is stimulated by the GTPase activating proteins (GAPs) Bem3p, Rga1p, and Rga2p. Once GTP is hydrolyzed, a guanine nucleotide exchange factor (GEF) (Cdc24p)promotes the exchange of GDP for GTP(3).
Last updated: 1999-11-24 
| 1) | Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states. J Cell Sci 113 ( Pt 3):365-75 |
| 2) | Johnson DI and Pringle JR (1990) Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J Cell Biol 111(1):143-52 |
| 3) | Madden K and Snyder M (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744 |
| 4) | Johnson DI (1999) Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev 63(1):54-105 |
| 5) | Ziman M, et al. (1993) Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol Biol Cell 4(12):1307-16 |
| 6) | Adams AE, et al. (1990) CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J Cell Biol 111(1):131-42 |
