CDC40/YDR364C Summary Help

Standard Name CDC40 1, 2
Systematic Name YDR364C
Alias PRP17 3 , SLT15 4 , SLU4 5
Feature Type ORF, Verified
Description Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats (6)
Name Description Cell Division Cycle 1
Chromosomal Location
ChrIV:1204210 to 1202843 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 211 cM
Gene Ontology Annotations All CDC40 GO evidence and references
  View Computational GO annotations for CDC40
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Classical genetics
Large-scale survey
135 total interaction(s) for 73 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 34
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Co-fractionation: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 4
  • Synthetic Growth Defect: 15
  • Synthetic Lethality: 46
  • Synthetic Rescue: 22

Expression Summary
Length (a.a.) 455
Molecular Weight (Da) 52,047
Isoelectric Point (pI) 7.2
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:1204210 to 1202843 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 211 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1368 1204210..1202843 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002772
References cited on this page View Complete Literature Guide for CDC40
1) Kassir Y and Simchen G  (1978) Meiotic recombination and DNA synthesis in a new cell cycle mutant of Saccharomyces cerevisiae. Genetics 90(1):49-68
2) Kassir, Y., et al.  (1985) Personal Communication, Mortimer Map Edition 9
3) Vijayraghavan U, et al.  (1989) Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae. Genes Dev 3(8):1206-16
4) Xu D, et al.  (1998) Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing. Mol Cell Biol 18(4):2055-66
5) Frank D, et al.  (1992) Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol 12(11):5197-205
6) Lindsey-Boltz LA, et al.  (2000) The carboxy terminal WD domain of the pre-mRNA splicing factor Prp17p is critical for function. RNA 6(9):1289-305