CDC39/YCR093W Summary Help

CDC39 BASIC INFORMATION

Standard Name CDC39 1, 2
Systematic Name YCR093W
Alias NOT1 3 , ROS1 , SMD6
Feature Type ORF, Verified
Description Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor (4, 5)
Name Description Cell Division Cycle 6
GO Annotations All CDC39 GO evidence and references
    View Computational GO annotations for CDC39
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All CDC39 Phenotype details and references
Classical genetics
conditional
reduction of function
unspecified
Large-scale survey
null
overexpression
Interactions CDC39 All interactions details and references
154 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 47
  • Affinity Capture-Western: 27
  • Co-fractionation: 1
  • Co-purification: 11
  • PCA: 19
  • Two-hybrid: 16
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 6
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 9
  • Synthetic Rescue: 12
Sequence Information
ChrIII:280114 to 286440 | ORF Map | GBrowse
This feature contains embedded feature(s): YCRX20C
Gbrowse
Genetic position: 91 cM
Last Update Coordinates: 2006-01-12 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..6327 280114..286440 2006-01-12 2000-09-13
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000689

CDC39 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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Expression Summary histogram

ADDITIONAL INFORMATION for CDC39

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC39]

1) Reed SI  (1980) The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95(3):561-77
2) Breter HJ, et al.  (1983) Isolation and transcriptional characterization of three genes which function at start, the controlling event of the Saccharomyces cerevisiae cell division cycle: CDC36, CDC37, and CDC39. Mol Cell Biol 3(5):881-91
3) Collart MA and Struhl K  (1994) NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev 8(5):525-37
4) Liu HY, et al.  (2001) Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme. J Biol Chem 276(10):7541-8
5) Russell P, et al.  (2002) Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex. J Mol Biol 322(1):27-39
6) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9