CDC33/YOL139C Summary

CDC33 BASIC INFORMATION

Standard Name	CDC33
Systematic Name	YOL139C
Alias	TIF45
Feature Type	ORF, Verified
Description	Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p) (1)
Name Description	Cell Division Cycle
Gene Product Alias	eIF4E

GO Annotations	All CDC33 GO evidence and references
	View Computational GO annotations for CDC33
Molecular Function
Manually curated	phosphatidylinositol 3-phosphate binding (IDA) translation initiation factor activity (ISS, TAS)
Biological Process
Manually curated	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (IDA, IPI) regulation of cell cycle (IMP) translational initiation (ISS, TAS)
Cellular Component
Manually curated	cytoplasm (IDA) eukaryotic translation initiation factor 4F complex (TAS) nucleus (IDA) ribosome (TAS) stress granule (IDA)

Mutant Phenotype	All CDC33 Phenotype details and references
Classical genetics
conditional	budding index: decreased cell cycle progression in G1 phase: increased duration cell cycle progression in G1 phase: arrested heat sensitivity: increased
Large-scale survey
null	fermentative growth: decreased rate inviable
overexpression	resistance to rapamycin: increased
repressible	cytokinesis: abnormal

Interactions	CDC33 All interactions details and references
	138 total interaction(s) for 81 unique genes/features.
Physical Interactions	Affinity Capture-MS: 93 Affinity Capture-RNA: 1 Affinity Capture-Western: 7 Biochemical Activity: 5 Far Western: 1 Reconstituted Complex: 3 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 6 Phenotypic Enhancement: 1 Synthetic Growth Defect: 5 Synthetic Lethality: 11 Synthetic Rescue: 2

Sequence Information

ChrXV:61024 to 60383 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..642	61024..60383	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005499

CDC33 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CDC33

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC33]

1)	Fortes P, et al. (2000) The yeast nuclear cap binding complex can interact with translation factor eIF4G and mediate translation initiation. Mol Cell 6(1):191-6

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