Standard Name	CDC33
Systematic Name	YOL139C
Alias	TIF45
Feature Type	ORF, Verified
Description	mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth (1, 2, 3)
Name Description	Cell Division Cycle
Gene Product Alias	eIF4E

Chromosomal Location	ChrXV:61024 to 60383 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CDC33
Molecular Function
Manually curated	phosphatidylinositol-3-phosphate binding (IDA) translation initiation factor activity (ISS, TAS)
Biological Process
Manually curated	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (IDA, IPI) regulation of cell cycle (IMP) translational initiation (ISS, TAS)
Cellular Component
Manually curated	cytoplasm (IDA) cytoplasmic stress granule (IDA) eukaryotic translation initiation factor 4F complex (TAS) nucleus (IDA) ribosome (TAS)

Classical genetics
conditional	adhesion: absent budding index: decreased cell cycle progression in G1 phase: arrested cell cycle progression in G1 phase: increased duration heat sensitivity: increased pseudohyphal growth: absent
Large-scale survey
null	fermentative growth: decreased rate haploinsufficient inviable
overexpression	resistance to sirolimus: increased
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased
repressible	cytokinesis: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	195 total interaction(s) for 119 unique genes/features.
Physical Interactions	Affinity Capture-MS: 117 Affinity Capture-RNA: 3 Affinity Capture-Western: 20 Biochemical Activity: 8 Far Western: 1 PCA: 2 Reconstituted Complex: 5 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 8 Negative Genetic: 1 Phenotypic Suppression: 2 Synthetic Growth Defect: 7 Synthetic Lethality: 14 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:61024 to 60383 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..642 61024..60383 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005499