Standard Name	CDC24
Systematic Name	YAL041W
Alias	CLS4
Feature Type	ORF, Verified
Description	Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress (1, 2, 3)
Name Description	Cell Division Cycle 4

Chromosomal Location	ChrI:62840 to 65404 | ORF Map | GBrowse
	Genetic position: -56 cM

	View Computational GO annotations for CDC24
Molecular Function
Manually curated	Rho guanyl-nucleotide exchange factor activity (TAS)
Biological Process
Manually curated	establishment of cell polarity (TAS) regulation of exit from mitosis (IMP) small GTPase mediated signal transduction (TAS)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) cytoplasm (IDA) incipient cellular bud site (IDA) mating projection tip (IDA) nucleus (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
conditional	budding: absent cell cycle progression: arrested cellular morphology: abnormal heat sensitivity: increased nuclear morphology: abnormal Sec3p-GFP distribution: abnormal shmoo formation: abnormal
unspecified	mating efficiency: decreased
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal
null	cell size: decreased heat sensitivity: increased inviable toxin resistance: increased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	251 total interaction(s) for 151 unique genes/features.
Physical Interactions	Affinity Capture-MS: 24 Affinity Capture-RNA: 1 Affinity Capture-Western: 20 Biochemical Activity: 1 Co-crystal Structure: 1 Co-fractionation: 2 PCA: 2 Protein-peptide: 1 Reconstituted Complex: 11 Two-hybrid: 33
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 25 Negative Genetic: 85 Phenotypic Enhancement: 2 Phenotypic Suppression: 5 Positive Genetic: 4 Synthetic Growth Defect: 3 Synthetic Lethality: 20 Synthetic Rescue: 10
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrI:62840 to 65404 | ORF Map | GBrowse
	Genetic position: -56 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2565 62840..65404 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000039