CDC15/YAR019C Summary Help

CDC15 BASIC INFORMATION

Standard Name CDC15 1
Systematic Name YAR019C
Alias LYT1
Feature Type ORF, Verified
Description Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II (2, 3)
Name Description Cell Division Cycle 4
GO Annotations All CDC15 GO evidence and references
    View Computational GO annotations for CDC15
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: cellcycle ( 287 )
Mutant Phenotype All CDC15 Phenotype details and references
Classical genetics
conditional
Large-scale survey
null
repressible
Interactions CDC15 All interactions details and references
145 total interaction(s) for 82 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 9
  • Biochemical Activity: 33
  • Co-localization: 6
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Lethality: 6
  • Dosage Rescue: 39
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 5
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 14
  • Synthetic Rescue: 9
Sequence Information
ChrI:175133 to 172209 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 6 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2925 175133..172209 2004-07-20 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000072

CDC15 RESOURCES

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Expression Summary histogram

ADDITIONAL INFORMATION for CDC15

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
HOF1Nomenclature conflictCDC15/YAR019C encodes a protein kinase involved in exit from mitosis. Do not confuse CDC15/YAR019C with pombe cdc15, which is similar to the cerevisiae HOF1/YMR032W gene.
CDC7Nomenclature conflictCDC7/YDL017W encodes a protein kinase involved in DNA replication. Do not confuse CDC7/YDL017W with pombe cdc7, which is similar to the cerevisiae CDC15/YAR019C gene, which encodes a protein kinase involved in cytokinesis.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC15]

1) Cid, V.J. and M.Sanchez  (1997) LYT1 is allelic to CDC15. Unpublished results
2) Bardin AJ, et al.  (2003) Mitotic exit regulation through distinct domains within the protein kinase Cdc15. Mol Cell Biol 23(14):5018-30
3) Pablo-Hernando ME, et al.  (2007) Cdc15 is required for spore morphogenesis independently of Cdc14 in Saccharomyces cerevisiae. Genetics 177(1):281-93
4) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9