CCZ1/YBR131W Summary Help

Standard Name CCZ1 1
Systematic Name YBR131W
Alias CVT16 2
Feature Type ORF, Verified
Description Protein involved in vacuolar assembly; essential for autophagy and the cytoplasm-to-vacuole pathway (2, 3)
Name Description Calcium Caffeine Zinc sensitivity 1
Chromosomal Location
ChrII:497163 to 499277 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CCZ1 GO evidence and references
  View Computational GO annotations for CCZ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
overexpression
reduction of function
Large-scale survey
null
overexpression
Resources
265 total interaction(s) for 172 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 5
  • Co-fractionation: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 155
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 63
  • Synthetic Growth Defect: 17
  • Synthetic Lethality: 6
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 704
Molecular Weight (Da) 80,732
Isoelectric Point (pI) 4.99
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:497163 to 499277 | ORF Map | GBrowse
This feature contains embedded feature(s): YBR131C-A
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2115 497163..499277 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000335
References cited on this page View Complete Literature Guide for CCZ1
1) Kucharczyk R, et al.  (1999) Disruption of six novel yeast genes located on chromosome II reveals one gene essential for vegetative growth and two required for sporulation and conferring hypersensitivity to various chemicals. Yeast 15(10B):987-1000
2) Meiling-Wesse K, et al.  (2002) Ccz1p/Aut11p/Cvt16p is essential for autophagy and the cvt pathway. FEBS Lett 526(1-3):71-6
3) Kucharczyk R, et al.  (2000) The novel protein Ccz1p required for vacuolar assembly in Saccharomyces cerevisiae functions in the same transport pathway as Ypt7p. J Cell Sci 113 Pt 23():4301-11