CCT4/YDL143W Summary Help

Standard Name CCT4
Systematic Name YDL143W
Alias TCP4 , ANC2 1
Feature Type ORF, Verified
Description Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo (1, 2)
Name Description Chaperonin Containing TCP-1
Chromosomal Location
ChrIV:199996 to 201582 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CCT4 GO evidence and references
  View Computational GO annotations for CCT4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
conditional
null
reduction of function
repressible
Resources
85 total interaction(s) for 71 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 47
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 1
  • Biochemical Activity: 2
  • Co-fractionation: 1
  • Co-purification: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 22
  • Phenotypic Suppression: 1
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 528
Molecular Weight (Da) 57,603
Isoelectric Point (pI) 7.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:199996 to 201582 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1587 199996..201582 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002302
References cited on this page View Complete Literature Guide for CCT4
1) Vinh DB and Drubin DG  (1994) A yeast TCP-1-like protein is required for actin function in vivo. Proc Natl Acad Sci U S A 91(19):9116-20
2) Chen X, et al.  (1994) Two yeast genes with similarity to TCP-1 are required for microtubule and actin function in vivo. Proc Natl Acad Sci U S A 91(19):9111-5