CCR4/YAL021C Summary Help

Standard Name CCR4 1, 2
Systematic Name YAL021C
Alias FUN27 , NUT21 3
Feature Type ORF, Verified
Description Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening (4, 5, 6)
Name Description Carbon Catabolite Repression 1
Chromosomal Location
ChrI:113359 to 110846 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -25 cM
Gene Ontology Annotations All CCR4 GO evidence and references
  View Computational GO annotations for CCR4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 10 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
476 total interaction(s) for 279 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 62
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 44
  • Biochemical Activity: 1
  • Co-fractionation: 2
  • Co-purification: 5
  • PCA: 6
  • Reconstituted Complex: 2
  • Two-hybrid: 22

Genetic Interactions
  • Dosage Growth Defect: 5
  • Dosage Lethality: 4
  • Dosage Rescue: 14
  • Negative Genetic: 19
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 12
  • Positive Genetic: 4
  • Synthetic Growth Defect: 142
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 103
  • Synthetic Rescue: 21

Resources
Expression Summary
histogram
Resources
Length (a.a.) 837
Molecular Weight (Da) 94,669
Isoelectric Point (pI) 6.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:113359 to 110846 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -25 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2514 113359..110846 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000019
References cited on this page View Complete Literature Guide for CCR4
1) Denis CL  (1984) Identification of new genes involved in the regulation of yeast alcohol dehydrogenase II. Genetics 108(4):833-44
2) Denis, C.  (1989) Personal Communication, Mortimer Map Edition 10
3) Tabtiang RK and Herskowitz I  (1998) Nuclear proteins Nut1p and Nut2p cooperate to negatively regulate a Swi4p-dependent lacZ reporter gene in Saccharomyces cerevisiae. Mol Cell Biol 18(8):4707-18
4) Liu HY, et al.  (1998) The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively. EMBO J 17(4):1096-106
5) Denis CL and Malvar T  (1990) The CCR4 gene from Saccharomyces cerevisiae is required for both nonfermentative and spt-mediated gene expression. Genetics 124(2):283-91
6) Tucker M, et al.  (2001) The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell 104(3):377-86