CBS1/YDL069C Summary Help

Standard Name CBS1 1
Systematic Name YDL069C
Feature Type ORF, Verified
Description Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader (2, 3, 4)
Name Description Cytochrome B Synthesis 1
Chromosomal Location
ChrIV:333810 to 333121 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CBS1 GO evidence and references
  View Computational GO annotations for CBS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
overexpression
reduction of function
Large-scale survey
null
Resources
11 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3

Genetic Interactions
  • Negative Genetic: 3
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 2
  • Synthetic Haploinsufficiency: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 229
Molecular Weight (Da) 26,586
Isoelectric Point (pI) 10.75
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:333810 to 333121 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2004-02-11 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..690 333810..333121 2004-02-11 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002227
References cited on this page View Complete Literature Guide for CBS1
1) Rodel G  (1986) Two yeast nuclear genes, CBS1 and CBS2, are required for translation of mitochondrial transcripts bearing the 5'-untranslated COB leader. Curr Genet 11(1):41-5
2) Michaelis U, et al.  (1991) Association of cytochrome b translational activator proteins with the mitochondrial membrane: implications for cytochrome b expression in yeast. Mol Gen Genet 230(1-2):177-85
3) Rodel G and Fox TD  (1987) The yeast nuclear gene CBS1 is required for translation of mitochondrial mRNAs bearing the cob 5' untranslated leader. Mol Gen Genet 206(1):45-50
4) Krause-Buchholz U, et al.  (2005) Saccharomyces cerevisiae translational activator Cbs1p is associated with translationally active mitochondrial ribosomes. Biol Chem 386(5):407-15