CBR1/YIL043C Summary Help

CBR1 BASIC INFORMATION

Standard Name CBR1
Systematic Name YIL043C
Alias CBR5
Feature Type ORF, Verified
Description Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia (1, 2, 3, 4)
Name Description Cytochrome b Reductase 2
GO Annotations All CBR1 GO evidence and references
    View Computational GO annotations for CBR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All CBR1 Phenotype details and references
Large-scale survey
null
Interactions CBR1 All interactions details and references
59 total interaction(s) for 42 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • PCA: 3
  • Two-hybrid: 1
Genetic Interactions
  • Phenotypic Enhancement: 13
  • Phenotypic Suppression: 14
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
Sequence Information
ChrIX:274925 to 274071 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2006-01-23 | Sequence: 2006-01-23
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..855 274925..274071 2006-01-23 2006-01-23
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001305

CBR1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CBR1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CBR1]

1) Kubota S, et al.  (1977) Studies on the microsomal electron-transport system of anaerobically grown yeast. IV. Purification and characterization of NADH-cytochrome b5 reductase. J Biochem 81(1):187-95
2) Csukai M, et al.  (1994) Isolation and complete sequence of CBR, a gene encoding a putative cytochrome b reductase in Saccharomyces cerevisiae. Eur J Biochem 219(1-2):441-8
3) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
4) Nussenzveig RH, et al.  (2006) A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia. Haematologica 91(11):1542-5