CBC2/YPL178W Summary Help

Standard Name CBC2 1
Systematic Name YPL178W
Alias MUD13 , SAE1 , CBP20
Feature Type ORF, Verified
Description Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif (2, 3, 4)
Name Description Cap Binding Complex 1
Chromosomal Location
ChrXVI:212158 to 212784 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CBC2 GO evidence and references
  View Computational GO annotations for CBC2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
406 total interaction(s) for 262 unique genes/features.
Physical Interactions
  • Affinity Capture-Luminescence: 1
  • Affinity Capture-MS: 177
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 17
  • Co-localization: 2
  • PCA: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 107
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 4
  • Positive Genetic: 24
  • Synthetic Growth Defect: 24
  • Synthetic Lethality: 22
  • Synthetic Rescue: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 208
Molecular Weight (Da) 23,774
Isoelectric Point (pI) 4.86
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:212158 to 212784 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..627 212158..212784 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006099
References cited on this page View Complete Literature Guide for CBC2
1) Das B, et al.  (2000) The role of nuclear cap binding protein Cbc1p of yeast in mRNA termination and degradation. Mol Cell Biol 20(8):2827-38
2) Shen EC, et al.  (2000) 7The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex. J Biol Chem 275(31):23718-24
3) Colot HV, et al.  (1996) The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complex. Genes Dev 10(13):1699-708
4) Lee-Soety JY, et al.  (2012) Yeast hnRNP-related proteins contribute to the maintenance of telomeres. Biochem Biophys Res Commun 426(1):12-7