CAT5/YOR125C Summary

CAT5 BASIC INFORMATION

Standard Name	CAT5
Systematic Name	YOR125C
Alias	COQ7
Feature Type	ORF, Verified
Description	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation (1, 2, 3, 4)
Name Description	CATabolite repression

GO Annotations	All CAT5 GO evidence and references
	View Computational GO annotations for CAT5
Molecular Function
Manually curated	monooxygenase activity (ISS)
Biological Process
Manually curated	ubiquinone biosynthetic process (IMP)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of ubiquinone biosynthesis ubiquinone biosynthesis

Mutant Phenotype	All CAT5 Phenotype details and references
Classical genetics
gain of function	mitochondrial genome maintenance: increased
null	lifespan: decreased respiratory growth: absent
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased fermentative growth: decreased rate resistance to nickel sulfate: decreased resistance to pyocyanin: increased respiratory growth: absent viable

Interactions	CAT5 All interactions details and references
	13 total interaction(s) for 13 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-fractionation: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Synthetic Growth Defect: 3

Sequence Information

ChrXV:559732 to 559031 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-05 | Sequence: 2003-09-22

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..702	559732..559031	2006-01-05	2003-09-22

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005651

CAT5 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CAT5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CAT5]

1)	Jonassen T, et al. (1998) Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis. J Biol Chem 273(6):3351-7
2)	Jonassen T, et al. (1996) Isolation and sequencing of the rat Coq7 gene and the mapping of mouse Coq7 to chromosome 7. Arch Biochem Biophys 330(2):285-9
3)	Marbois BN and Clarke CF (1996) The COQ7 gene encodes a protein in saccharomyces cerevisiae necessary for ubiquinone biosynthesis. J Biol Chem 271(6):2995-3004
4)	Hsieh EJ, et al. (2007) Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex. Arch Biochem Biophys 463(1):19-26

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