CAT2/YML042W Summary Help

Standard Name CAT2 1
Systematic Name YML042W
Alias YCAT
Feature Type ORF, Verified
Description Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes (1, 2, 3)
Name Description Carnitine AcetylTransferase 1
Chromosomal Location
ChrXIII:192788 to 194800 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CAT2 GO evidence and references
  View Computational GO annotations for CAT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Pathways
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
unspecified
Resources
35 total interaction(s) for 33 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 3
  • Two-hybrid: 12

Genetic Interactions
  • Negative Genetic: 9
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 670
Molecular Weight (Da) 77,241
Isoelectric Point (pI) 8.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:192788 to 194800 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2013 192788..194800 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004506
References cited on this page View Complete Literature Guide for CAT2
1) Elgersma Y, et al.  (1995) Peroxisomal and mitochondrial carnitine acetyltransferases of Saccharomyces cerevisiae are encoded by a single gene. EMBO J 14(14):3472-9
2) van Roermund CW, et al.  (1999) Molecular characterization of carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria in Saccharomyces cerevisiae and identification of a plasma membrane carnitine transporter, Agp2p. EMBO J 18(21):5843-52
3) Swiegers JH, et al.  (2001) Carnitine-dependent metabolic activities in Saccharomyces cerevisiae: three carnitine acetyltransferases are essential in a carnitine-dependent strain. Yeast 18(7):585-95