Standard Name	CAP2 1
Systematic Name	YIL034C
Feature Type	ORF, Verified
Description	Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress (1, 2, 3)
Name Description	CAPping 1

Chromosomal Location	ChrIX:290089 to 289226 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -28 cM

	View Computational GO annotations for CAP2
Molecular Function
Manually curated	actin filament binding (IGI, IMP, IPI, ISS)
Biological Process
Manually curated	barbed-end actin filament capping (IDA) filamentous growth (IMP)
Cellular Component
Manually curated	actin cortical patch (IDA) actin filament (IPI) F-actin capping protein complex (IDA, IGI, IMP, IPI, ISS)
High-throughput	cellular bud tip (IDA) mating projection tip (IDA) plasma membrane (IDA)

Classical genetics
null	cell size: increased endocytosis: decreased actin distribution: abnormal chitin distribution: abnormal
Large-scale survey
null	cell size: increased competitive fitness: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased hyperosmotic stress resistance: decreased mitochondrial genome maintenance: abnormal resistance to caffeine: increased resistance to methyl methanesulfonate: increased resistance to tunicamycin: increased resistance to ethanol: decreased resistance to fenpropimorph: decreased resistance to fluconazole: decreased resistance to mycophenolic acid: decreased resistance to hydroxyurea: increased toxin resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	116 total interaction(s) for 78 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Biochemical Activity: 2 PCA: 10 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 48 Phenotypic Enhancement: 1 Positive Genetic: 3 Synthetic Growth Defect: 15 Synthetic Lethality: 16 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:290089 to 289226 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -28 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..864 290089..289226 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001296