CAP2/YIL034C Summary

CAP2 BASIC INFORMATION

Standard Name	CAP2 1
Systematic Name	YIL034C
Feature Type	ORF, Verified
Description	Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches (1, 2)
Name Description	CAPping 1

GO Annotations	All CAP2 GO evidence and references
	View Computational GO annotations for CAP2
Molecular Function
Manually curated	actin filament binding (IGI, IMP, IPI, ISS)
Biological Process
Manually curated	barbed-end actin filament capping (IDA) filamentous growth (IMP)
Cellular Component
Manually curated	actin cortical patch (IDA) actin filament (IPI) F-actin capping protein complex (IDA, IGI, IMP, IPI, ISS)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All CAP2 Phenotype details and references
Classical genetics
null	cell size: increased chitin distribution: abnormal actin distribution: abnormal
Large-scale survey
null	competitive fitness: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased mitochondrial genome maintenance: abnormal resistance to ethanol: decreased viable

Interactions	CAP2 All interactions details and references
	57 total interaction(s) for 41 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 2 PCA: 9 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Phenotypic Enhancement: 1 Synthetic Growth Defect: 7 Synthetic Lethality: 20 Synthetic Rescue: 1

Sequence Information

ChrIX:290088 to 289225 | |

Note: this feature is encoded on the Crick strand.

Genetic position: -28 cM

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..864	290088..289225	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001296

CAP2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CAP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CAP2]

1)	Amatruda JF, et al. (1990) Disruption of the actin cytoskeleton in yeast capping protein mutants. Nature 344(6264):352-4
2)	Kim K, et al. (2004) Capping protein binding to actin in yeast: biochemical mechanism and physiological relevance. J Cell Biol 164(4):567-80

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