CAP2/YIL034C Summary Help

Standard Name CAP2 1
Systematic Name YIL034C
Feature Type ORF, Verified
Description Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress (1, 2, 3)
Name Description CAPping 1
Chromosomal Location
ChrIX:290089 to 289226 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -28 cM
Gene Ontology Annotations All CAP2 GO evidence and references
  View Computational GO annotations for CAP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
117 total interaction(s) for 78 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • PCA: 10
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 48
  • Phenotypic Enhancement: 1
  • Positive Genetic: 3
  • Synthetic Growth Defect: 15
  • Synthetic Lethality: 16
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 287
Molecular Weight (Da) 32,629
Isoelectric Point (pI) 4.36
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:290089 to 289226 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -28 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..864 290089..289226 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001296
References cited on this page View Complete Literature Guide for CAP2
1) Amatruda JF, et al.  (1990) Disruption of the actin cytoskeleton in yeast capping protein mutants. Nature 344(6264):352-4
2) Kim K, et al.  (2004) Capping protein binding to actin in yeast: biochemical mechanism and physiological relevance. J Cell Biol 164(4):567-80
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76