CAP1/YKL007W Summary Help

Standard Name CAP1 1
Systematic Name YKL007W
Feature Type ORF, Verified
Description Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress (2, 3)
Name Description CAPping 4
Chromosomal Location
ChrXI:429302 to 430108 | ORF Map | GBrowse
Gbrowse
Genetic position: -2 cM
Gene Ontology Annotations All CAP1 GO evidence and references
  View Computational GO annotations for CAP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 13 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
137 total interaction(s) for 91 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 29
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 62
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Positive Genetic: 6
  • Synthetic Growth Defect: 16
  • Synthetic Lethality: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 268
Molecular Weight (Da) 30,699
Isoelectric Point (pI) 5.06
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:429302 to 430108 | ORF Map | GBrowse
SGD ORF map
Genetic position: -2 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..807 429302..430108 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001490
References cited on this page View Complete Literature Guide for CAP1
1) Amatruda JF, et al.  (1992) Effects of null mutations and overexpression of capping protein on morphogenesis, actin distribution and polarized secretion in yeast. J Cell Biol 119(5):1151-62
2) Kim K, et al.  (2004) Capping protein binding to actin in yeast: biochemical mechanism and physiological relevance. J Cell Biol 164(4):567-80
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
4) Amatruda JF, et al.  (1990) Disruption of the actin cytoskeleton in yeast capping protein mutants. Nature 344(6264):352-4