Standard Name	CAP1
Systematic Name	YKL007W
Feature Type	ORF, Verified
Description	Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress (1, 2)
Name Description	CAPping 3

Chromosomal Location	ChrXI:429302 to 430108 | ORF Map | GBrowse
	Genetic position: -2 cM

	View Computational GO annotations for CAP1
Molecular Function
Manually curated	actin filament binding (IGI, IMP, IPI, ISS)
Biological Process
Manually curated	barbed-end actin filament capping (IDA)
Cellular Component
Manually curated	actin cortical patch (IDA) actin filament (IPI) F-actin capping protein complex (IDA, IGI, IMP, IPI, ISS)
High-throughput	cellular bud neck (IDA) cellular bud tip (IDA) mating projection tip (IDA) plasma membrane (IDA)

Classical genetics
null	endocytosis: decreased Bud8p-GFP distribution: abnormal
Large-scale survey
null	bud morphology: abnormal budding pattern: abnormal cell shape: abnormal cell size: increased competitive fitness: decreased endocytosis: decreased haploinsufficient heat sensitivity: increased resistance to bleomycin: increased resistance to fenpropimorph: decreased resistance to cycloheximide: decreased resistance to hydroxyurea: increased resistance to neothyonidioside: decreased resistance to fluconazole: decreased stress resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	133 total interaction(s) for 88 unique genes/features.
Physical Interactions	Affinity Capture-MS: 28 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 62 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 4 Synthetic Growth Defect: 15 Synthetic Lethality: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:429302 to 430108 | ORF Map | GBrowse
	Genetic position: -2 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..807 429302..430108 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001490