CAP1/YKL007W Summary

CAP1 BASIC INFORMATION

Standard Name	CAP1
Systematic Name	YKL007W
Feature Type	ORF, Verified
Description	Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches (1)
Name Description	CAPping 2

GO Annotations	All CAP1 GO evidence and references
	View Computational GO annotations for CAP1
Molecular Function
Manually curated	actin filament binding (IGI, IMP, IPI, ISS)
Biological Process
Manually curated	barbed-end actin filament capping (IDA)
Cellular Component
Manually curated	actin cortical patch (IDA) actin filament (IPI) F-actin capping protein complex (IDA, IGI, IMP, IPI, ISS)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All CAP1 Phenotype details and references
Classical genetics
null	Bud8p-GFP distribution: abnormal
Large-scale survey
null	bud morphology: abnormal budding pattern: abnormal cell shape: abnormal cell size: increased competitive fitness: decreased viable

Interactions	CAP1 All interactions details and references
	55 total interaction(s) for 39 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-RNA: 1 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Synthetic Growth Defect: 8 Synthetic Lethality: 14

Sequence Information

ChrXI:428945 to 429751 | |

Genetic position: -2 cM

Last Update

Coordinates: 2005-12-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..807	428945..429751	2005-12-15	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001490

CAP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CAP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CAP1]

1)	Kim K, et al. (2004) Capping protein binding to actin in yeast: biochemical mechanism and physiological relevance. J Cell Biol 164(4):567-80
2)	Amatruda JF, et al. (1990) Disruption of the actin cytoskeleton in yeast capping protein mutants. Nature 344(6264):352-4

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