Standard Name	CAN1 1
Systematic Name	YEL063C
Feature Type	ORF, Verified
Description	Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7)
Name Description	CANavanine resistance 3

Chromosomal Location	ChrV:33466 to 31694 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -50 cM

	View Computational GO annotations for CAN1
Molecular Function
Manually curated	arginine transmembrane transporter activity (IMP) basic amino acid transmembrane transporter activity (IDA)
Biological Process
Manually curated	arginine transport (IGI) basic amino acid transport (IDA) transmembrane transport (IDA)
Cellular Component
Manually curated	membrane raft (IDA) plasma membrane (IDA)
High-throughput	integral to membrane (ISM) mitochondrion (IDA)

Classical genetics
unspecified	auxotrophy nutrient uptake: arrested stress resistance: increased
Large-scale survey
null	endocytosis: decreased resistance to L-canavanine: increased starvation resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	66 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 1 Co-localization: 2 PCA: 45 Protein-RNA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Positive Genetic: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:33466 to 31694 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -50 cM
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1773 33466..31694 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000000789