CAK1/YFL029C Summary

CAK1 BASIC INFORMATION

Standard Name	CAK1
Systematic Name	YFL029C
Alias	CIV1 1
Feature Type	ORF, Verified
Description	Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases (2, 3)
Name Description	Cdk-Activating Kinase 4

GO Annotations	All CAK1 GO evidence and references
	View Computational GO annotations for CAK1
Molecular Function
Manually curated	cyclin-dependent protein kinase activating kinase activity (IDA, IMP, IPI)
Biological Process
Manually curated	G1 phase of mitotic cell cycle (IMP) G2/M transition of mitotic cell cycle (IMP) meiosis (IGI, IMP) protein amino acid phosphorylation (IDA, IMP)
Cellular Component
Manually curated	cytoplasm (IDA)

Mutant Phenotype	All CAK1 Phenotype details and references
Classical genetics
null	SIC1 accumulation: decreased
Large-scale survey
null	alkaline pH resistance: decreased inviable resistance to sulfanilamide: decreased

Interactions	CAK1 All interactions details and references
	152 total interaction(s) for 111 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-Western: 1 Biochemical Activity: 7 Reconstituted Complex: 1 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 6 Phenotypic Enhancement: 36 Phenotypic Suppression: 69 Synthetic Growth Defect: 3 Synthetic Lethality: 13 Synthetic Rescue: 8

Sequence Information

ChrVI:79159 to 78053 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1107	79159..78053	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001865

CAK1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CAK1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CAK1]

1)	Thuret JY, et al. (1996) Civ1 (CAK in vivo), a novel Cdk-activating kinase. Cell 86(4):565-76
2)	Enke DA, et al. (1999) The CDK-activating kinase (Cak1p) from budding yeast has an unusual ATP-binding pocket. J Biol Chem 274(4):1949-56
3)	Enke DA, et al. (2000) Kinetic analysis of the cyclin-dependent kinase-activating kinase (Cak1p) from budding yeast. J Biol Chem 275(43):33267-71
4)	Kaldis P, et al. (2000) The effects of changing the site of activating phosphorylation in CDK2 from threonine to serine. J Biol Chem 275(42):32578-84

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