CAK1/YFL029C Summary Help

Standard Name CAK1 1
Systematic Name YFL029C
Alias CIV1 2
Feature Type ORF, Verified
Description Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases (3, 4)
Name Description Cdk-Activating Kinase 1
Chromosomal Location
ChrVI:79161 to 78055 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CAK1 GO evidence and references
  View Computational GO annotations for CAK1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
162 total interaction(s) for 118 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-Western: 1
  • Biochemical Activity: 8
  • Co-purification: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 6
  • Negative Genetic: 36
  • Phenotypic Suppression: 2
  • Positive Genetic: 66
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 15
  • Synthetic Rescue: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 368
Molecular Weight (Da) 42,186
Isoelectric Point (pI) 5.71
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVI:79161 to 78055 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1107 79161..78055 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001865
References cited on this page View Complete Literature Guide for CAK1
1) Kaldis P, et al.  (1996) The Cdk-activating kinase (CAK) from budding yeast. Cell 86(4):553-64
2) Thuret JY, et al.  (1996) Civ1 (CAK in vivo), a novel Cdk-activating kinase. Cell 86(4):565-76
3) Enke DA, et al.  (1999) The CDK-activating kinase (Cak1p) from budding yeast has an unusual ATP-binding pocket. J Biol Chem 274(4):1949-56
4) Enke DA, et al.  (2000) Kinetic analysis of the cyclin-dependent kinase-activating kinase (Cak1p) from budding yeast. J Biol Chem 275(43):33267-71