CAF4/YKR036C Summary

CAF4 BASIC INFORMATION

Standard Name	CAF4 1
Systematic Name	YKR036C
Feature Type	ORF, Verified
Description	WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission (1, 2)
Name Description	CCR4 Associated Factor 1

GO Annotations	All CAF4 GO evidence and references
	View Computational GO annotations for CAF4
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitochondrial fission (IMP, IPI) peroxisome fission (IGI) regulation of transcription from RNA polymerase II promoter (IMP, IPI)
Cellular Component
Manually curated	CCR4-NOT complex (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All CAF4 Phenotype details and references
Classical genetics
null	resistance to hydroxyurea: normal viable
Large-scale survey
null	competitive fitness: decreased viable
overexpression	vegetative growth: decreased

Interactions	CAF4 All interactions details and references
	38 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-Western: 5 Co-crystal Structure: 1 Co-localization: 3 Two-hybrid: 11
Genetic Interactions	Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Synthetic Rescue: 1

Sequence Information

ChrXI:510275 to 508344 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-05-08 | Sequence: 2006-05-08

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1932	510275..508344	2006-05-08	2006-05-08

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001744

CAF4 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CAF4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CAF4]

1)	Liu HY, et al. (2001) Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme. J Biol Chem 276(10):7541-8
2)	Griffin EE, et al. (2005) The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria. J Cell Biol 170(2):237-48

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