CAF16/YFL028C Summary

CAF16 BASIC INFORMATION

Standard Name	CAF16 1
Systematic Name	YFL028C
Feature Type	ORF, Verified
Description	Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator (1, 2)
Name Description	CCR4 Associated Factor 1

GO Annotations	All CAF16 GO evidence and references
	View Computational GO annotations for CAF16
Molecular Function
Manually curated	ATPase activity (ISS)
Biological Process
Manually curated	regulation of transcription from RNA polymerase II promoter (IMP, IPI)
Cellular Component
Manually curated	CCR4-NOT complex (IDA)
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All CAF16 Phenotype details and references
Classical genetics
null	resistance to hydroxyurea: normal viable
Large-scale survey
null	viable

Interactions	CAF16 All interactions details and references
	12 total interaction(s) for 10 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Biochemical Activity: 1 Two-hybrid: 4
Genetic Interactions	Phenotypic Enhancement: 2 Phenotypic Suppression: 4

Sequence Information

ChrVI:80211 to 79342 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..870	80211..79342	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001866

CAF16 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CAF16

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CAF16]

1)	Liu HY, et al. (2001) Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme. J Biol Chem 276(10):7541-8
2)	Bauer BE, et al. (1999) Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Biochim Biophys Acta 1461(2):217-36

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