CAF120/YNL278W Summary Help

Standard Name CAF120 1
Systematic Name YNL278W
Feature Type ORF, Verified
Description Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication (1, 2)
Name Description CCR4 Associated Factor 1
Chromosomal Location
ChrXIV:113271 to 116453 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CAF120 GO evidence and references
  View Computational GO annotations for CAF120
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
33 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 1
  • Protein-RNA: 1

Genetic Interactions
  • Dosage Growth Defect: 7
  • Dosage Rescue: 2
  • Negative Genetic: 10
  • Positive Genetic: 4
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,060
Molecular Weight (Da) 118,279
Isoelectric Point (pI) 9.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:113271 to 116453 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3183 113271..116453 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005222
References cited on this page View Complete Literature Guide for CAF120
1) Chen J, et al.  (2001) Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. J Mol Biol 314(4):683-94
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61