CAD1/YDR423C Summary Help

CAD1 BASIC INFORMATION

Standard Name CAD1 1
Systematic Name YDR423C
Alias YAP2
Feature Type ORF, Verified
Description AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA (2, 3, 4, 5, 6, 7, 8)
Name Description CADmium resistance 9
GO Annotations All CAD1 GO evidence and references
    View Computational GO annotations for CAD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs CAD1 Transcription Factor Binding Sites and References
  • MTTASTMAKC
  • TTACTAA
Regulatory modules predicted: stressResponse ( 649 , 439 , 427 , 367 )
Mutant Phenotype All CAD1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions CAD1 All interactions details and references
12 total interaction(s) for 9 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 1
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 3
Sequence Information
ChrIV:1319268 to 1318039 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 271 cM
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1230 1319268..1318039 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002831

CAD1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CAD1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CAD1]

1) Januska, A.  (1989) Personal Communication, Mortimer Map Edition 10
2) Lesuisse E and Labbe P  (1995) Effects of cadmium and of YAP1 and CAD1/YAP2 genes on iron metabolism in the yeast Saccharomyces cerevisiae. Microbiology 141 ( Pt 11):2937-43
3) Vilela C, et al.  (1998) The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability. Nucleic Acids Res 26(5):1150-9
4) Hirata D, et al.  (1994) Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae. Mol Gen Genet 242(3):250-6
5) Miyahara K, et al.  (1996) yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae. Curr Genet 29(2):103-5
6) Fernandes L, et al.  (1997) Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol 17(12):6982-93
7) Vilela C, et al.  (1999) Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stability. EMBO J 18(11):3139-52
8) Cohen BA, et al.  (2002) Discrimination between paralogs using microarray analysis: application to the Yap1p and Yap2p transcriptional networks. Mol Biol Cell 13(5):1608-14
9) Wu A, et al.  (1993) Yeast bZip proteins mediate pleiotropic drug and metal resistance. J Biol Chem 268(25):18850-8