Standard Name	CAB3 1
Systematic Name	YKL088W
Feature Type	ORF, Verified
Description	Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC (1, 2, 3, 4)
Name Description	Coenzyme A Biosynthesis 1

Chromosomal Location	ChrXI:275283 to 276998 | ORF Map | GBrowse

	View Computational GO annotations for CAB3
Molecular Function
Manually curated	contributes_to phosphopantothenoylcysteine decarboxylase activity (IDA, IMP) phosphopantothenoylcysteine decarboxylase activity (ISS) purine nucleotide binding (ISS)
High-throughput	phosphopantothenoylcysteine decarboxylase activity (ISS)
Biological Process
Manually curated	coenzyme A biosynthetic process (IGI, ISS) response to salt stress (IGI)
High-throughput	coenzyme A biosynthetic process (ISS)
Cellular Component
Manually curated	phosphopantothenoylcysteine decarboxylase complex (IDA)
High-throughput	cytoplasm (IDA)

Pathways	pantothenate and coenzyme A biosynthesis

Classical genetics
null	inviable
overexpression	ionic stress resistance: decreased
Large-scale survey
conditional	heat sensitivity: increased
null	inviable
reduction of function	competitive fitness: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	50 total interaction(s) for 25 unique genes/features.
Physical Interactions	Affinity Capture-MS: 30 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 PCA: 13 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:275283 to 276998 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1716 275283..276998 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001571