CAB1/YDR531W Summary Help

Standard Name CAB1 1
Systematic Name YDR531W
Feature Type ORF, Verified
Description Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase; catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element (2, 3)
Name Description Coenzyme A Biosynthesis 1
Chromosomal Location
ChrIV:1498232 to 1499335 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CAB1 GO evidence and references
  View Computational GO annotations for CAB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Pathways
Classical genetics
conditional
null
Large-scale survey
conditional
null
reduction of function
Resources
80 total interaction(s) for 74 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Biochemical Activity: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 63
  • Positive Genetic: 13
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 367
Molecular Weight (Da) 40,903
Isoelectric Point (pI) 6.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1498232 to 1499335 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1104 1498232..1499335 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002939
References cited on this page View Complete Literature Guide for CAB1
1) Olzhausen J, et al.  (2009) Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Curr Genet 55(2):163-73
2) Calder RB, et al.  (1999) Cloning and characterization of a eukaryotic pantothenate kinase gene (panK) from Aspergillus nidulans. J Biol Chem 274(4):2014-20
3) Brohee S, et al.  (2011) Unraveling networks of co-regulated genes on the sole basis of genome sequences. Nucleic Acids Res 39(15):6340-58