Standard Name	BXI1 1
Systematic Name	YNL305C
Alias	YBH3 2
Feature Type	ORF, Verified
Description	Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p (1, 2, 3, 4, 5)
Name Description	BaX Inhibitor 1

Chromosomal Location	ChrXIV:59791 to 58898 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for BXI1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	apoptotic process (IMP) calcium-mediated signaling (IMP) endoplasmic reticulum unfolded protein response (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) fungal-type vacuole (IDA) mitochondrion (IDA)
High-throughput	fungal-type vacuole (IDA) integral to membrane (ISM)

Classical genetics
null	apoptosis: increased apoptosis: decreased chronological lifespan: increased replicative lifespan: increased resistance to tunicamycin: decreased resistance to mercaptoethanol: decreased resistance to hypochlorous acid: decreased thermotolerance: decreased
overexpression	cell death: increased
Large-scale survey
null	competitive fitness: decreased resistance to streptomycin: decreased resistance to amitrole: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
overexpression	resistance to sirolimus: decreased vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	24 total interaction(s) for 18 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 Protein-RNA: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Synthetic Growth Defect: 2 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:59791 to 58898 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..894 59791..58898 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005249