BUR6/YER159C Summary Help

BUR6 BASIC INFORMATION

Standard Name BUR6
Systematic Name YER159C
Alias NCB1
Feature Type ORF, Verified
Description Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha (1, 2, 3, 4)
Name Description Bypass UAS Requirement 5
GO Annotations All BUR6 GO evidence and references
    View Computational GO annotations for BUR6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All BUR6 Phenotype details and references
Classical genetics
unspecified
Large-scale survey
null
Interactions BUR6 All interactions details and references
54 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 8
  • Co-localization: 3
  • PCA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 4
  • Phenotypic Suppression: 1
  • Synthetic Lethality: 6
  • Synthetic Rescue: 24
Sequence Information
ChrV:491953 to 491525 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..429 491953..491525 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000961

BUR6 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for BUR6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BUR6]

1) Kim S, et al.  (1997) The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Proc Natl Acad Sci U S A 94(3):820-5
2) Goppelt A and Meisterernst M  (1996) Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae. Nucleic Acids Res 24(22):4450-5
3) Estruch F and Cole CN  (2003) An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components. Mol Biol Cell 14(4):1664-76
4) Cang Y and Prelich G  (2002) Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Proc Natl Acad Sci U S A 99(20):12727-32
5) Prelich G and Winston F  (1993) Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo. Genetics 135(3):665-76