Standard Name	BUR2 1
Systematic Name	YLR226W
Alias	CST4
Feature Type	ORF, Verified
Description	Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II (2, 3, 4)
Name Description	Bypass UAS Requirement 1

Chromosomal Location	ChrXII:589354 to 590541 | ORF Map | GBrowse

	View Computational GO annotations for BUR2
Molecular Function
Manually curated	cyclin-dependent protein serine/threonine kinase regulator activity (IDA, IPI, ISS)
Biological Process
Manually curated	mitotic sister chromatid segregation (IGI) phosphorylation of RNA polymerase II C-terminal domain (IMP) positive regulation of histone H3-K4 methylation (IMP) positive regulation of histone ubiquitination (IMP) transcription, DNA-dependent (IDA, IMP, IPI)
Cellular Component
Manually curated	cyclin-dependent protein kinase holoenzyme complex (IPI)
High-throughput	nucleus (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal metal resistance: decreased Rpo21p modification: decreased Spt5-TAP modification: decreased
overexpression	colony sectoring: increased resistance to benomyl: decreased
unspecified	auxotrophy
Large-scale survey
null	alkaline pH resistance: decreased budding index: decreased cell cycle progression in G1 phase: delayed cell size: increased polyphosphate accumulation: abnormal glutathione excretion: increased competitive fitness: decreased fermentative growth: decreased rate heat sensitivity: increased lipid particle morphology: abnormal resistance to 1,4-dithiothreitol: decreased resistance to tunicamycin: decreased resistance to cadmium dichloride: decreased resistance to hygromycin B: decreased resistance to cycloheximide: decreased resistance to methyl methanesulfonate: decreased resistance to CTBT: decreased resistance to caffeine: decreased resistance to (S)-lactic acid: decreased resistance to L-1,4-dithiothreitol: decreased resistance to cisplatin: decreased resistance to amitrole: decreased resistance to sorbate: decreased small molecule transport: decreased stress resistance: decreased utilization of nitrogen source: absent vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	colony sectoring: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	88 total interaction(s) for 56 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 PCA: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 3 Phenotypic Suppression: 2 Synthetic Growth Defect: 15 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 33 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:589354 to 590541 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1188 589354..590541 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004216