BUG1/YDL099W Summary Help

Standard Name BUG1 1
Systematic Name YDL099W
Feature Type ORF, Verified
Description Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes (1, 2)
Name Description Binder of USO1 and GRH1 1
Chromosomal Location
ChrIV:283419 to 284444 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All BUG1 GO evidence and references
  View Computational GO annotations for BUG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 101 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
105 total interaction(s) for 65 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 1
  • Biochemical Activity: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 41
  • Phenotypic Enhancement: 20
  • Phenotypic Suppression: 5
  • Positive Genetic: 20
  • Synthetic Growth Defect: 5
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 341
Molecular Weight (Da) 38,294
Isoelectric Point (pI) 4.36
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:283419 to 284444 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1026 283419..284444 2004-02-11 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002257
References cited on this page View Complete Literature Guide for BUG1
1) Schuldiner M, et al.  (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19
2) Behnia R, et al.  (2007) The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic. J Cell Biol 176(3):255-61