BUG1/YDL099W Summary

BUG1 BASIC INFORMATION

Standard Name	BUG1 1
Systematic Name	YDL099W
Feature Type	ORF, Verified
Description	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes (1, 2)
Name Description	Binder of USO1 and GRH1 1

GO Annotations	All BUG1 GO evidence and references
	View Computational GO annotations for BUG1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IGI, IMP, IPI)
Cellular Component
Manually curated	cis-Golgi network (IDA, IPI)
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All BUG1 Phenotype details and references
Classical genetics
null	KAR2 secretion: abnormal
Large-scale survey
null	respiratory growth: absent viable

Interactions	BUG1 All interactions details and references
	51 total interaction(s) for 33 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 2 Two-hybrid: 2
Genetic Interactions	Phenotypic Enhancement: 28 Phenotypic Suppression: 13 Synthetic Growth Defect: 2

Sequence Information

ChrIV:283419 to 284444 | |

Last Update

Coordinates: 2004-02-11 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1026	283419..284444	2004-02-11	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002257

BUG1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for BUG1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BUG1]

1)	Schuldiner M, et al. (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19
2)	Behnia R, et al. (2007) The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic. J Cell Biol 176(3):255-61

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