BUD2/YKL092C Summary Help

BUD2 BASIC INFORMATION

Standard Name BUD2 1
Systematic Name YKL092C
Alias CLA2 , ERC25
Feature Type ORF, Verified
Description GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types (1, 2 and see Summary Paragraph)
Name Description BUD site selection
GO Annotations All BUD2 GO evidence and references
    View Computational GO annotations for BUD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All BUD2 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions BUD2 All interactions details and references
10 total interaction(s) for 8 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Biochemical Activity: 1
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
Sequence Information
ChrXI:269103 to 265789 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3315 269103..265789 2005-12-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001575

BUD2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for BUD2

SUMMARY PARAGRAPH for BUD2

BUD2 encodes a GTPase-activating protein (GAP) for the small GTPase Rsr1p (3, 2). Along with the GTP/GDP exchange factor Bud5p, Bud2p regulates the activity of Rsr1p and thereby helps control bud site selection in growing cells (3). Deletion or over-expression of BUD2 causes yeast cells to bud randomly in all cell types, instead of in the usual axial pattern in haploids and bipolar pattern in a/alpha diploids (1, 2). When budding is conceptually divided into three steps, choice of a growth site, organization of the growth site, and actual growth and morphogenesis, Rsr1p and its negative regulator Bud2p and positive regulator Bud5p are the key players in the initial step of the process (4).

Last updated: 1999-09-01

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BUD2]

1) Chant J and Herskowitz I  (1991) Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway. Cell 65(7):1203-12
2) Park HO, et al.  (1993) BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast. Nature 365(6443):269-74
3) Bender A  (1993) Genetic evidence for the roles of the bud-site-selection genes BUD5 and BUD2 in control of the Rsr1p (Bud1p) GTPase in yeast. Proc Natl Acad Sci U S A 90(21):9926-9
4) Cabib E, et al.  (1998) Role of small G proteins in yeast cell polarization and wall biosynthesis. Annu Rev Biochem 67:307-33