Standard Name	BTN2
Systematic Name	YGR142W
Feature Type	ORF, Verified
Description	v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	BaTteN disease 6

Chromosomal Location	ChrVII:772454 to 773686 | ORF Map | GBrowse

	View Computational GO annotations for BTN2
Molecular Function
Manually curated	chaperone binding (IPI) SNARE binding (IDA, IPI)
Biological Process
Manually curated	amino acid transport (IMP) intracellular protein transport (IMP, IPI) protein folding (IGI, IMP, IPI) protein localization to nucleus (IMP, IPI) regulation of pH (IGI, IMP) retrograde transport, endosome to Golgi (IMP)
Cellular Component
Manually curated	cytosol (IDA) late endosome (IDA) nucleus (IDA) perinuclear region of cytoplasm (IDA)

Classical genetics
null	acid pH resistance: decreased hydrostatic pressure resistance: decreased nutrient uptake: increased prion formation: increased prion loss: decreased vacuolar H(+)-ATPase activity: increased Rhb1p distribution: abnormal GFP-Yif1p distribution: abnormal Sis1p-GFP distribution: abnormal resistance to ethanol: decreased resistance to Calcofluor White: increased resistance to canavanine: decreased toxin resistance: increased viable
overexpression	budding: abnormal nutrient uptake: decreased prion loss: increased Sis1p-GFP distribution: abnormal
Large-scale survey
null	competitive fitness: decreased sporulation: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	58 total interaction(s) for 42 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 2 Affinity Capture-Western: 15 Co-localization: 3 Reconstituted Complex: 1 Two-hybrid: 11
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Negative Genetic: 10 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Positive Genetic: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:772454 to 773686 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1233 772454..773686 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003374