BTN2/YGR142W Summary Help

Standard Name BTN2 1
Systematic Name YGR142W
Feature Type ORF, Verified
Description v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; contributes to prion curing; BTN2 has a paralog, CUR1, that arose from the whole genome duplication (2, 3, 4, 5, 6, 7)
Name Description BaTteN disease 1
Chromosomal Location
ChrVII:772454 to 773686 | ORF Map | GBrowse
Gene Ontology Annotations All BTN2 GO evidence and references
  View Computational GO annotations for BTN2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 27 genes
Classical genetics
Large-scale survey
58 total interaction(s) for 42 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 15
  • Co-localization: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Negative Genetic: 10
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Expression Summary
Length (a.a.) 410
Molecular Weight (Da) 47,167
Isoelectric Point (pI) 4.93
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:772454 to 773686 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1233 772454..773686 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003374
References cited on this page View Complete Literature Guide for BTN2
1) Pearce DA, et al.  (1999) Action of BTN1, the yeast orthologue of the gene mutated in Batten disease. Nat Genet 22(1):55-8
2) Chattopadhyay S, et al.  (2000) The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis. J Bacteriol 182(22):6418-23
3) Chattopadhyay S and Pearce DA  (2002) Interaction with Btn2p is required for localization of Rsglp: Btn2p-mediated changes in arginine uptake in Saccharomyces cerevisiae. Eukaryot Cell 1(4):606-12
4) Chattopadhyay S, et al.  (2003) The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p. Biochem Biophys Res Commun 302(3):534-8
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Kama R, et al.  (2007) Btn2, a hook1 ortholog and potential batten disease-related protein, mediates late endosome-Golgi protein sorting in yeast. Mol Cell Biol 27(2):605-21
7) Wickner RB, et al.  (2014) Normal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variants. Proc Natl Acad Sci U S A 111(26):E2711-20