BSD2/YBR290W Summary Help

Standard Name BSD2 1
Systematic Name YBR290W
Feature Type ORF, Verified
Description Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification (1, 2, 3)
Name Description Bypass Sod1p Defects 4
Chromosomal Location
ChrII:782591 to 783556 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All BSD2 GO evidence and references
  View Computational GO annotations for BSD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 140 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Resources
154 total interaction(s) for 119 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Biochemical Activity: 1
  • PCA: 36
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 46
  • Phenotypic Enhancement: 15
  • Phenotypic Suppression: 1
  • Positive Genetic: 18
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 1
  • Synthetic Rescue: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 321
Molecular Weight (Da) 35,763
Isoelectric Point (pI) 4.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:782591 to 783556 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..966 782591..783556 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000494
References cited on this page View Complete Literature Guide for BSD2
1) Liu XF and Culotta VC  (1994) The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene. Mol Cell Biol 14(11):7037-45
2) Liu XF, et al.  (1997) Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene. J Biol Chem 272(18):11763-9
3) Portnoy ME, et al.  (2000) Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters. Mol Cell Biol 20(21):7893-902
4) Lapinskas PJ, et al.  (1995) Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutase. Mol Cell Biol 15(3):1382-8