Standard Name	BSD2
Systematic Name	YBR290W
Feature Type	ORF, Verified
Description	Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification (1, 2, 3)
Name Description	Bypass Sod1p Defects 4

Chromosomal Location	ChrII:782591 to 783556 | ORF Map | GBrowse

	View Computational GO annotations for BSD2
Molecular Function
Manually curated	protein binding (IPI)
Biological Process
Manually curated	metal ion transport (IMP) protein targeting to vacuole (IMP) ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) fungal-type vacuole membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	alkaline pH resistance: decreased cadmium(2+) accumulation: increased cobalt(2+) accumulation: increased metal resistance: decreased resistance to cadmium(2+): decreased resistance to copper(2+): decreased
reduction of function	GFP-Smf1-deltaN transport: abnormal GFP-Cps1 transport: abnormal resistance to cadmium(2+): decreased
Large-scale survey
null	inositol excretion: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient resistance to cycloheximide: decreased resistance to pyocyanin: decreased resistance to selenomethionine: increased resistance to nickel sulfate: increased resistance to sirolimus: decreased resistance to acetic acid: decreased resistance to clioquinol: decreased resistance to wortmannin: normal resistance to BPS: decreased resistance to fluconazole: decreased stress resistance: increased vacuolar morphology: abnormal viable
overexpression	resistance to sirolimus: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	139 total interaction(s) for 108 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 Biochemical Activity: 1 PCA: 36 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 36 Phenotypic Enhancement: 15 Phenotypic Suppression: 1 Positive Genetic: 14 Synthetic Growth Defect: 10 Synthetic Lethality: 1 Synthetic Rescue: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:782591 to 783556 | ORF Map | GBrowse
	This feature is contained within: 70380
	This feature is contained within: 70946
	This feature is contained within: 70961
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..966 782591..783556 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000494