BRR1/YPR057W Summary

BRR1 BASIC INFORMATION

Standard Name	BRR1
Systematic Name	YPR057W
Feature Type	ORF, Verified
Description	snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed (1, 2, 3)
Name Description	Bad Response to Refrigeration 1

GO Annotations	All BRR1 GO evidence and references
	View Computational GO annotations for BRR1
Molecular Function
Manually curated	RNA binding (IPI)
Biological Process
Manually curated	spliceosome assembly (IMP)
Cellular Component
Manually curated	small nuclear ribonucleoprotein complex (IDA)

Mutant Phenotype	All BRR1 Phenotype details and references
Classical genetics
conditional	cold sensitivity: increased
null	spliceosomal snRNAs accumulation: decreased
Large-scale survey
null	bud morphology: abnormal glycogen accumulation: increased competitive fitness: decreased fermentative growth: decreased rate viable

Interactions	BRR1 All interactions details and references
	120 total interaction(s) for 113 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1
Genetic Interactions	Phenotypic Enhancement: 46 Phenotypic Suppression: 50 Synthetic Growth Defect: 8 Synthetic Lethality: 4

Sequence Information

ChrXVI:672468 to 673493 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1026	672468..673493	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006261

BRR1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for BRR1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for BRR1]

1)	Noble SM and Guthrie C (1996) Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 143(1):67-80
2)	Noble SM and Guthrie C (1996) Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. EMBO J 15(16):4368-79
3)	Liu Q, et al. (1997) The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. Cell 90(6):1013-21

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.